executive summary格式:抗肿瘤药物

executive summary格式:抗肿瘤药物

MDR是成功完成化疗治疗癌症的最大挑战。有一种复杂的机制涉及到一些影响相同的因素,如蛋白质功能、ABC转运蛋白和挤压药物和毒素。生存素是凋亡抑制剂家族中的一种新成员。在细胞凋亡控制和细胞分裂的情况下,功能作用是可能的。这是在人类癌症的情况下进行的,使其成为治疗癌症的一个新的潜在目标。为了克服MDR,一些小分子化合物被应用于像异丙嗪、环孢素A和维拉帕米等功能抑制剂。然而,他们未知的药代动力学与毒性和化疗药物的相互作用限制了他们在诊所的使用。

executive summary格式:抗肿瘤药物
另外有报道称,在纳米颗粒内的化疗药物的封装可能最终避免药物流出的泵。这进一步增加了细胞内药物的浓度。这很少显示抗肿瘤的作用。此外,这种浓度的升高并没有导致细胞在阻断凋亡通路上的死亡。在最近的研究中发现,当基因编码表达被沉默时,MDR可以部分逆转。他们在体内抗肿瘤的实验结果显示,在不降低肿瘤体积的情况下,可以减少肿瘤的生长。

executive summary格式:抗肿瘤药物

MDR is the biggest challenge faced in successfully completing chemotherapy for the treatment of cancer. There is a complicated mechanism involved with several factors affecting the same such as proteins functioning, ABC transporters and extrude drugs and toxins. Survivin is a new member in the family of apoptosis inhibitors. The functional role is possible in the case of apoptosis control and cell division. This is up regulated in case of human cancers that make it a new potential target for the treatment of cancer. For the purpose of overcoming MDR, some compounds of small molecule were utilized in the form of functional inhibitors like promethazine, cyclosporine A and verapamil. However, their unknown pharmacokinetic interaction with toxicities and chemotherapeutics restricted their utilization in clinics.

executive summary格式:抗肿瘤药物
Additional reports were made that the encapsulation of chemotherapeutic agents within nanoparticles could end up evading the pumps of drug efflux. This further ended up increasing the concentration of intracellular drug. This rarely showed the effects of anti- tumor. In addition, such increased level of concentration did not lead towards proportionately increasing death of cell on blocking the apoptosis pathway. It was recently investigated and discovered that MDR can enable partial reversal as the gene coding expression is silenced. Their experiments on in vivo anti-tumor only ended up exhibiting the capability to reduce the growth of tumor but without decreasing the volume of tumor.

 

 

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