英国论文格式:机械传感器SWELL1

英国论文格式:机械传感器SWELL1

也有假说认为,机械传感器SWELL1具有感知脂肪细胞大小的能力,通过调节胰岛素- pi3k – akt介导的脂肪分解和细胞葡萄糖摄取,在调节脂滴生长中发挥重要作用。这是一种独特的创新,因为脂肪细胞生物学(fat – cycte biology,简称fat -patch-biology)领域有了一种新的分析方法,对天然脂肪细胞环境中的SWELL 1表达、调控进行了研究。探索了肥胖条件下诱导增生性脂肪细胞等新颖的离子通道。SWELL1的独特作用是维持脂肪细胞的脂质条件,并在体外和体内分析中发现基础pAKT信号。除此之外,本研究还提出了创新性的实验方法,旨在了解和开发具有开拓性的方法,包括利用CRISPR/Cas9技术在体外和体内条件基因敲除,从而更快、更长期地解决脂肪细胞靶向SWELL1敲除/下调的问题。


英国论文格式:机械传感器SWELL1
关于脂肪细胞及其可塑性的潜在分子机制对于理解肥胖至关重要。脂肪细胞能够通过形成脂滴来最大限度地储存能量。它只与薄的细胞质边缘(约300纳米)分离。该细胞具有独特的能力,能将表面积扩大> 10倍,体积扩大>30倍,以适应肥胖。这就引出了一个问题,即不断增长的脂滴与质膜相互作用以增加膜张力之间的关系。近年来的生物工程研究对脂肪细胞脂滴大小与脂肪细胞刚度和膜顺应性之间的关系有了一定的认识。以往的经验数据表明,通过增加细胞膜中的脂滴,可以发现未被发现的拉伸传感器,从而了解脂质合成途径。

英国论文格式:机械传感器SWELL1

It has also been hypothesized that the mechanosensor SWELL1 has the ability to sense the adipocyte size and play an important role in the regulation of the growth of the lipid droplet by tuning insulin-PI3K-Akt- mediated lipolysis and cellular glucose uptake. This is unique and innovative because there has been a new analysis of the field of adipocycte biology (Adipocye-patch-biology) has been done to investiaget about the SWELL 1 expression, regulation in the native adipocycte environment. Unique ion channel that are novel such as the induced hypertrophic adipocyte during the conditions of obesity has been probed. The unique role of SWELL1 is maintaining the adipocyte lipid conditions has been probed along with the basal pAKT signaling that is found in both in vitro and in vivo analysis. Apart from this, the innovative experimental approach has been proposed in this research to understand and develop pioneering methods to achive faster and long term solutions for adipocyte targeted SWELL1 knock-out/down including the use of CRISPR/Cas9 technology in vitro and in vivo conditional gene knock-outs.


英国论文格式:机械传感器SWELL1
Underlying molecular mechanisms regarding adipocyte and its plasticity is essential to understand about obesity. Adipocyte has the ability to maximize energy storage by formation of a lipid droplet. It is only separated from a thin rim (~300 nm) of cytoplasm. This cell has the unique ability to enlarge the surface area by > 10-fold and volume by >30-fold to adapt to obesity. This leads to the question of understanding of the relation between the growing lipid droplets to interact with the plasma membrane to increase the membrane tension. The recent bioengineering studies have developed understanding about the link between the adipocyte lipid droplet size with the adipocyte stiffness and membrane compliance. Previous empirical data suggests that by increasing the lipid droplet in the cell membrane there can be undiscovered stretch-sensor which leads to the understanding of the lipid synthesis pathways.

COPYRIGHT © ADVANCED THESIS ALL RIGHTS RESERVED 高阶英国论文代写 | OUR SERVICES ARE TO BE USED FOR RESEARCH AND REFERENCE PURPOSES ONLY